Trpa1 Gene Summary [Rat]
Enables osmolarity-sensing monoatomic cation channel activity and voltage-gated calcium channel activity. Involved in several processes, including cellular response to caffeine; cellular response to carbon dioxide; and positive regulation of transport. Located in apical plasma membrane and axon. Used to study asthma; diabetic neuropathy; and overactive bladder syndrome. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Orthologous to human TRPA1 (transient receptor potential cation channel subfamily A member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trpa1 |
| Official Name | transient receptor potential cation channel, subfamily A, member 1 [Source:RGD Symbol;Acc:1303284] |
| Ensembl ID | ENSRNOG00000007354 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel, subfamily A, member 1 |
| Synonyms | ANKTM1, FEPS, FEPS1, p120, transient receptor potential cation channel subfamily A member 1, transient receptor potential cation channel, subfamily A, member 1, TRPA1b |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Trpa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- osmosensor
- Ankyrin repeats (many copies)
- Ion transport protein
- calcium channel
- channel/pore class transporter
- Ankyrin repeats (3 copies)
- inorganic uptake permease
- protein binding
- identical protein binding
- calcium-release channel
- ion channel
- Ankyrin repeat
- voltage-gated calcium channel
- transient-receptor-potential calcium channel protein
- cation channel
- Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
- Polycystin cation channel
- transporter
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Trpa1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart disease
- mechanical hypersensitivity
- edema
- cardiac fibrosis
- pain
- cold pain
- familial episodic pain syndrome type 1
- cold allodynia
- inflammatory pain
- hyperplasia
role in cell
- expression in
- apoptosis
- proliferation
- cellular infiltration by
- disruption
- disruption in
- quantity
- activation
- M1 polarization
- excitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
- stereocilia
- apical membrane
- nerve ending
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Trpa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell surface receptor signaling pathway
- response to organic cyclic compound
- response to xenobiotic stimulus
- cellular calcium ion homeostasis
- response to pain
- response to cold
- ion transport
- protein homotetramerization
- detection of chemical stimulus involved in sensory perception of pain
- calcium ion transmembrane transport
- sensory perception of pain
- detection of mechanical stimulus involved in sensory perception of pain
- thermoception
- cellular response to hydrogen peroxide
- calcium-mediated signaling
Cellular Component
Where in the cell the gene product is active
- stereocilium bundle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- calcium-release channel activity
- channel activity
- calcium channel activity