Chmp3 Gene Summary [Rat]
Enables phosphatidylinositol-4,5-bisphosphate binding activity. Involved in endosome to lysosome transport; positive regulation of cytokinesis; and regulation of endosome size. Located in early endosome; late endosome; and midbody. Orthologous to several human genes including CHMP3 (charged multivesicular body protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chmp3 |
| Official Name | charged multivesicular body protein 3 [Source:RGD Symbol;Acc:708556] |
| Ensembl ID | ENSRNOG00000007356 |
| Bio databases IDs | |
| Aliases | charged multivesicular body protein 3 |
| Synonyms | 25.1, 4921505F14Rik, 9130011K15Rik, CGI-149, CGI-49, Charged Multivesicular Body Protein 3, D6Ertd286e, NEDF, VPS24 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chmp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- binding protein
- protease binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- identical protein binding
- Snf7
Pathways
Biological processes and signaling networks where the Chmp3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neuroticism
role in cell
- expression in
- degradation in
- internalization in
- quantity
- degradation
- autophagy by
- assembly
- reassembly
- cell-to-cell spreading
- cell-to-cell spreading in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- cellular membrane
- Plasma Membrane
- midbody
- cytosol
- lysosome membrane
- nuclear pores
- autophagic vacuoles
- early endosomes
- late endosomes
- cytoplasmic vesicles
- multivesicular bodies
- kinetochore microtubule
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chmp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- protein transport
- late endosome to vacuole transport
- nucleus organization
- protein polymerization
- regulation of endosome size
- non-lytic virus budding from plasma membrane
- release of virus from host
- regulation of centrosome duplication
- plasma membrane repair
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- autophagy
- apoptotic process
- endosome transport via multivesicular body sorting pathway
- multivesicular body sorting pathway
- nuclear envelope reassembly
- mitotic metaphase plate congression
- positive regulation of cytokinesis
- macroautophagy
- regulation of early endosome to late endosome transport
- vesicle fusion with vacuole
Cellular Component
Where in the cell the gene product is active
- ESCRT III complex
- late endosome
- kinetochore
- multivesicular body
- lysosomal membrane
- autophagic vacuole membrane
- plasma membrane
- nuclear pore
- early endosome
- extracellular vesicular exosome
- kinetochore microtubule
- cytoplasmic vesicle
- cytosol
- midbody
- multivesicular body membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- phosphatidylcholine binding