Tagap Gene Summary [Rat]
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of Rho protein signal transduction and signal transduction. Predicted to act upstream of or within defense response to virus. Orthologous to human TAGAP (T cell activation RhoGTPase activating protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tagap |
| Official Name | T-cell activation RhoGTPase activating protein [Source:RGD Symbol;Acc:1308618] |
| Ensembl ID | ENSRNOG00000018915 |
| Bio databases IDs | |
| Aliases | T-cell activation RhoGTPase activating protein |
| Synonyms | 2610315E15RIK, ARHGAP47, FKSG15, IDDM21, LOC100038946, TAGAP1, Tcd-1, Tcd1a, T-cell activation RhoGTPase activating protein, tcs-1, TRD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tagap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- GTPase activator
- protein binding
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- inflammatory bowel disease
- rheumatoid arthritis
- celiac disease
- Crohn disease
- psoriasis
- multiple sclerosis
- ulcerative colitis
- autoimmune disease
- hypothyroidism
- systemic lupus erythematosus
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tagap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Rho protein signal transduction
- signal transduction
- regulation of small GTPase mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- GTPase activator activity