Clp1 Gene Summary [Rat]
This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Details
| Type | Protein Coding |
| Official Symbol | Clp1 |
| Official Name | cleavage and polyadenylation factor I subunit 1 [Source:RGD Symbol;Acc:1307679] |
| Ensembl ID | ENSRNOG00000007416 |
| Bio databases IDs | |
| Aliases | cleavage and polyadenylation factor I subunit 1 |
| Synonyms | cleavage factor polyribonucleotide kinase subunit 1, CLP1, cleavage and polyadenylation factor I subunit, hClp1, HEAB, RGD1307679 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Clp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- N-terminal beta-sandwich domain of polyadenylation factor
- Pre-mRNA cleavage complex II protein Clp1
- 50S ribosome-binding GTPase
- ATP binding
- protein binding
- polynucleotide 5'-hydroxyl-kinase
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- paralysis
- pathological denervation
- pontocerebellar hypoplasia type 10
- major depression
- alcohol use disorder
- respiratory failure
- non-syndromic congenital pontocerebellar hypoplasia
regulated by
- topotecan
- SCp2 cells
- camptothecin
- MMP3
regulates
- RISC
- CFII
role in cell
- loss
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Clp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA splicing, via endonucleolytic cleavage and ligation
- mRNA 3'-end processing
- small RNA loading onto RISC
- cerebellar cortex development
Cellular Component
Where in the cell the gene product is active
- nucleus
- mRNA cleavage factor complex
- cytosol
- tRNA-intron endonuclease complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- polynucleotide 5'-hydroxyl-kinase activity
- protein binding
- ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
- ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity