Apip Gene Summary [Rat]
Predicted to enable identical protein binding activity; methylthioribulose 1-phosphate dehydratase activity; and zinc ion binding activity. Predicted to be involved in several processes, including L-methionine salvage from methylthioadenosine; protein homotetramerization; and pyroptotic inflammatory response. Predicted to act upstream of or within negative regulation of apoptotic process. Predicted to be located in endomembrane system. Predicted to be active in cytoplasm. Orthologous to human APIP (APAF1 interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apip |
| Official Name | APAF1 interacting protein [Source:RGD Symbol;Acc:1564562] |
| Ensembl ID | ENSRNOG00000007446 |
| Bio databases IDs | |
| Aliases | APAF1 interacting protein |
| Synonyms | APAF1 interacting protein, APIP2, CGI-29, hAPIP, LOC100044135, MMRP19, Monocyte Macrophage19, RGD1564562 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Apip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methylthioribulose 1-phosphate dehydratase
- Aldolase_II
- Class II Aldolase and Adducin N-terminal domain
- zinc ion binding
- 5-methylthioribulose-1-phosphate 4-dehydratase
- enzyme
- protein binding
- identical protein binding
- methylthioribulose-1-phosphate dehydratase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Apip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ERK1 and ERK2 cascade
- protein homotetramerization
- L-methionine biosynthetic process from S-adenosylmethionine
- L-methionine salvage from methylthioadenosine
- negative regulation of apoptotic process
- apoptotic process
- pyroptosis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- methylthioribulose 1-phosphate dehydratase activity
- identical protein binding
- zinc ion binding
- protein binding