Casp9 Gene Summary [Rat]
Enables cysteine-type peptidase activity. Involved in several processes, including response to anesthetic; response to indole-3-methanol; and response to ischemia. Located in cytoplasm. Used to study pre-malignant neoplasm. Biomarker of several diseases, including brain disease (multiple); bronchopulmonary dysplasia; heart disease (multiple); kidney disease (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (caspase 9). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Casp9 |
| Official Name | caspase 9 [Source:RGD Symbol;Acc:61867] |
| Ensembl ID | ENSRNOG00000012944 |
| Bio databases IDs | |
| Aliases | caspase 9 |
| Synonyms | APAF-3, CAS-9, Casp9 v1, Caspase-9, ICE-LAP6, MCH6, PPP1R56, Procaspase-9 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Casp9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Akt phosphorylation site
- protein kinase binding
- catalytic domain
- peptidase
- enzyme
- protein binding
- enzyme activator activity
- identical protein binding
- SH3-domain binding
- phosphorylation site
- CASc
- Caspase recruitment domain
- cysteine-type peptidase
- cysteine endopeptidase
- interdomain cleavage site
- active site
- pro domain
- Death Domain Superfamily of protein-protein interaction domains
Pathways
Biological processes and signaling networks where the Casp9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Angiopoietin Signaling
- Apoptosis Signaling
- CD27 Signaling in Lymphocytes
- DNA damage-induced 14-3-3σ Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endometrial Cancer Signaling
- Endoplasmic Reticulum Stress Pathway
- Endothelin-1 Signaling
- eNOS Signaling
- Granzyme B Signaling
- HER-2 Signaling in Breast Cancer
- Induction of Apoptosis by HIV1
- Lymphotoxin β Receptor Signaling
- Molecular Mechanisms of Cancer
- MYC Mediated Apoptosis Signaling
- Non-Small Cell Lung Cancer Signaling
- Parkinson's Signaling
- Retinoic acid Mediated Apoptosis Signaling
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Small Cell Lung Cancer Signaling
- TNFR1 Signaling
- Tumoricidal Function of Hepatic Natural Killer Cells
- TWEAK Signaling
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- cancer
- Alzheimer disease
- neurological disorder
- bleeding
- alcoholic pancreatitis
- thrombocytopenia
- salivary duct carcinoma
- salivary duct cancer
role in cell
- apoptosis
- growth
- formation
- formation in
- migration
- expression in
- activation in
- cell death
- number
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- presynaptic regions
- Nucleus
- Mitochondria
- midbody
- apoptosome
- cytosol
- mitochondrial intermembrane space
- synaptosomes
- axons
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Casp9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction in response to DNA damage
- intrinsic apoptotic signaling pathway
- positive regulation of neuron apoptotic process
- response to ischemia
- response to hypoxia
- kidney development
- apoptotic process
- platelet formation
- cellular response to UV
- response to cobalt ion
- protein maturation
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- glial cell apoptotic process
- neuron apoptotic process
- DNA damage response, signal transduction resulting in induction of apoptosis
- fibroblast apoptotic process
- response to DNA damage stimulus
- activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
- positive regulation of apoptotic process
- response to estradiol stimulus
- leukocyte apoptotic process
- response to lipopolysaccharide
- protein processing
- cellular response to dexamethasone stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- apoptosome
- cytoplasm
- mitochondrion
- cytosol
- macromolecular complex
- caspase complex
Molecular Function
What the gene product does at the molecular level
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- protein kinase binding
- protein binding
- cysteine-type endopeptidase activity
- enzyme activator activity
- SH3 domain binding
- peptidase activity
- cysteine-type endopeptidase activity involved in apoptotic process