Ehd4 Gene Summary [Rat]
Predicted to enable protein-macromolecule adaptor activity. Involved in several processes, including pinocytosis; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of endocytosis. Predicted to be located in endoplasmic reticulum. Predicted to be active in several cellular components, including adherens junction; cytoplasmic vesicle; and perinuclear region of cytoplasm. Orthologous to human EHD4 (EH domain containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ehd4 |
| Official Name | EH-domain containing 4 [Source:RGD Symbol;Acc:628883] |
| Ensembl ID | ENSRNOG00000007584 |
| Bio databases IDs | |
| Aliases | EH-domain containing 4 |
| Synonyms | 2210022F10RIK, EH-domain containing 4, Past2, PAST4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ehd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP-binding domain
- nucleic acid binding
- protein binding activity, bridging
- 50S ribosome-binding GTPase
- EFh
- enzyme
- protein binding
- N-terminal EH-domain containing protein
- Dynamin family
- Domain of unknown function (DUF5600)
- Eps15 homology domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- Cytoskeletal-regulatory complex EF hand
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- non-insulin-dependent diabetes mellitus
- hyperplasia
- side effect
- mesangiolysis
- progressive supranuclear palsy
- systemic juvenile idiopathic arthritis
- oligozoospermia
- proteinuria
role in cell
- number
- proliferation
- apoptosis
- effacement
- survival
- formation
- endocytosis by
- pinocytosis by
- macroendocytosis in
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- perinuclear region
- Nucleus
- endosomes
- Endoplasmic Reticulum
- granules
- cytoplasmic aggregates
- cytosol
- membrane ruffles
- plasma membrane extracellular face
- endosomal membrane
- extracellular matrix
- axon terminals
- exosomes
- cell-cell adherens junctions
- plasma
- cartilage matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ehd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- cellular response to growth factor stimulus
- protein homooligomerization
- pinocytosis
- regulation of endocytosis
- endocytosis
- positive regulation of peptidyl-tyrosine phosphorylation
- endocytic recycling
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- endocytic vesicle
- nucleus
- early endosome
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- endoplasmic reticulum
- recycling endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- nucleic acid binding
- ATP binding
- protein binding
- calcium ion binding
- cadherin binding