Ehd1 Gene Summary [Rat]
Predicted to enable identical protein binding activity and small GTPase binding activity. Involved in cellular response to nerve growth factor stimulus; neuron projection development; and positive regulation of neuron projection development. Located in endosome membrane. Is active in glutamatergic synapse and presynaptic active zone. Biomarker of obesity. Orthologous to human EHD1 (EH domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ehd1 |
| Official Name | EH-domain containing 1 [Source:RGD Symbol;Acc:1309017] |
| Ensembl ID | ENSRNOG00000043503 |
| Bio databases IDs | |
| Aliases | EH-domain containing 1 |
| Synonyms | EH-domain containing 1, H-PAST, HPAST1, Mpast1, PAST, PAST1, RGD1306960, RME-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ehd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF5600)
- 50S ribosome-binding GTPase
- enzyme binding
- EFh
- Eps15 homology domain
- protein binding
- GTP binding motif, P-loop
- identical protein binding
- N-terminal EH-domain containing protein
- P-loop containing Nucleoside Triphosphate Hydrolases
- Cytoskeletal-regulatory complex EF hand
- Dynamin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- Ewing sarcoma
- experimental autoimmune encephalomyelitis
- malocclusion
- organismal death
- anophthalmia
- congenital malformation
- microphthalmia
- azoospermia
role in cell
- expression in
- morphology
- growth
- quantity
- proliferation
- phosphorylation in
- migration
- apoptosis
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- glutaminergic synapse
- cilia
- perinuclear membrane
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- lipid droplets
- cytosol
- endosomal membrane
- synapse
- early endosomes
- endocytotic vesicle
- microsomal membrane
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ehd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- low-density lipoprotein particle clearance
- cilium morphogenesis
- neuron projection development
- protein homooligomerization
- intracellular protein transport
- endocytosis
- cholesterol homeostasis
- positive regulation of endocytic recycling
- positive regulation of cholesterol storage
- positive regulation of neuron projection development
- protein localization in plasma membrane
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- platelet dense tubular network membrane
- flagellar pocket membrane
- plasma membrane
- lipid particle
- early endosome membrane
- endocytic vesicle
- early endosome
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoplasm
- membrane
- endosome membrane
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ATP binding
- identical protein binding
- protein binding
- cadherin binding
- calcium ion binding
- small GTPase binding