Cmpk2 Gene Summary [Rat]
Enables UMP/dUMP kinase activity and dTMP kinase activity. Involved in dTDP biosynthetic process and dUDP biosynthetic process. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Orthologous to human CMPK2 (cytidine/uridine monophosphate kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cmpk2 |
| Official Name | cytidine/uridine monophosphate kinase 2 [Source:RGD Symbol;Acc:1305881] |
| Ensembl ID | ENSRNOG00000007690 |
| Bio databases IDs | |
| Aliases | cytidine/uridine monophosphate kinase 2 |
| Synonyms | 1200004E04Rik, cytidine/uridine monophosphate kinase 2, IBGC10, LOC129607, NDK, TDKI, TMPK2, TYKi, UMP-CMPK2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cmpk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- dTMP kinase
- nucleoside diphosphate kinase
- NK
- cytidylate kinase
- uridylate kinase
- UMP kinase
- Thymidylate kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- systemic lupus erythematosus
- diabetes mellitus
- colorectal cancer
- ATAD3A-related type I interferonopathy
- HER2 negative hormone receptor negative breast cancer
- acute respiratory distress syndrome
role in cell
- production in
- proliferation
- activation in
- binding in
- maturation in
- synthesis in
- oxidation in
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cmpk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to lipopolysaccharide
- dTDP biosynthetic process
- nucleoside monophosphate phosphorylation
- dUDP biosynthetic process
- dTTP biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cytidylate kinase activity
- thymidylate kinase activity
- ATP binding
- UMP kinase activity
- nucleoside diphosphate kinase activity