Casp1 Gene Summary [Rat]
Enables scaffold protein binding activity. Involved in several processes, including microglial cell activation; positive regulation of circadian sleep/wake cycle, non-REM sleep; and positive regulation of interleukin-1 beta production. Part of protein-containing complex. Used to study acute kidney failure. Biomarker of myocardial infarction. Orthologous to several human genes including CASP1 (caspase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Casp1 |
| Official Name | caspase 1 [Source:RGD Symbol;Acc:2274] |
| Ensembl ID | ENSRNOG00000007372 |
| Bio databases IDs | |
| Aliases | caspase 1 |
| Synonyms | Caspase-1, ICE, IL1BC, interleukin 1-beta convertase, interleukin-1beta converting enzyme, interleukin 1-β convertase, interleukin 1 β converting enzyme, Interleukin-1 β (IL-1 β) converting enzyme, P45, pro-casp-1, Procaspase-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Casp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- cytokine binding
- catalytic domain
- peptidase
- caspase activator
- protein binding
- identical protein binding
- caspase
- CASc
- Caspase recruitment domain
- endopeptidase
- cysteine endopeptidase
- CARD-like domain
- kinase binding
- active site
- pro domain
- Death Domain Superfamily of protein-protein interaction domains
Pathways
Biological processes and signaling networks where the Casp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- DNA damage-induced 14-3-3σ Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endothelin-1 Signaling
- Granzyme A Signaling
- Huntington's Disease Signaling
- Inflammasome pathway
- Neuroinflammation Signaling Pathway
- Osteoarthritis Pathway
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PKR in Interferon Induction and Antiviral Response
- Sphingosine-1-phosphate Signaling
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- relapsing-remitting multiple sclerosis
- Alzheimer disease
- septic shock
- complete testicular feminization syndrome
- chronic pancreatitis
- sepsis
- pancreatic cancer
- systemic inflammatory response syndrome
role in cell
- activation in
- cell death
- binding in
- expression in
- degradation in
- survival
- tubulation
- cell viability
- synthesis in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- cytosol
- membrane processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Casp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- osmosensory signaling pathway
- positive regulation of inflammatory response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of apoptotic process
- icosanoid biosynthetic process
- defense response to bacterium
- pattern recognition receptor signaling pathway
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- cellular response to mechanical stimulus
- cellular response to lipopolysaccharide
- apoptotic process
- proteolysis
- pyroptosis
- regulation of inflammatory response
- positive regulation of interleukin-18 production
- defense response to virus
- protein autoprocessing
- protein maturation
- cellular response to interferon-gamma
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- protease inhibitor complex
- cytoplasm
- AIM2 inflammasome complex
- NLRP1 inflammasome complex
- cytosol
- IPAF inflammasome complex
- macromolecular complex
- nucleolus
- plasma membrane
- NLRP3 inflammasome complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- cysteine-type endopeptidase activity
- endopeptidase activity
- CARD domain binding
- cytokine binding
- cysteine-type endopeptidase activator activity involved in apoptotic process
- kinase binding