Tex15 Gene Summary [Rat]

Predicted to be involved in meiotic nuclear division; regulation of double-strand break repair via homologous recombination; and transposable element silencing by piRNA-mediated DNA methylation. Predicted to act upstream of or within with a positive effect on DNA methylation-dependent constitutive heterochromatin formation. Predicted to act upstream of or within several processes, including homeostasis of number of cells within a tissue; homologous chromosome pairing at meiosis; and male genitalia development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in spermatogenic failure 25. Orthologous to human TEX15 (testis expressed 15, meiosis and synapsis associated). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Tex15
Official Name
testis expressed 15, meiosis and synapsis associated [Source:RGD Symbol;Acc:1311266]
Ensembl ID
ENSRNOG00000007748
Bio databases IDs NCBI: 290803 Ensembl: ENSRNOG00000007748
Aliases testis expressed 15, meiosis and synapsis associated
Synonyms 2210014E14Rik, CT42, SPGF25, testis expressed 15, meiosis and synapsis associated, testis expressed gene 15 meiosis and synapsis associated
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tex15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Protein of unknown function (DUF3715)
  • Testis expressed sequence 15
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • spermatogenic failure 25
  • spermatogenic failure 1
regulated by
role in cell
  • formation
  • fertilization
  • synapsis in
  • meiosis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • Cytoplasm
  • Nucleus

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Tex15 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • DNA repair
  • negative regulation of transposition, RNA-mediated
  • male meiosis
  • spermatogenesis
  • synaptonemal complex assembly
  • cell differentiation
  • piRNA metabolic process
  • regulation of double-strand break repair via homologous recombination
  • methylation-dependent chromatin silencing

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytoplasm

Gene-Specific Assays for Results You Can Trust

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