Serpinc1 Gene Summary [Rat]
Enables heparin binding activity and serine-type endopeptidase inhibitor activity. Involved in acute inflammatory response to antigenic stimulus; lactation; and response to nutrient. Located in extracellular space. Used to study thrombosis. Biomarker of familial hyperlipidemia; nephrotic syndrome; and ovarian cancer. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (serpin family C member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpinc1 |
| Official Name | serpin family C member 1 [Source:RGD Symbol;Acc:1307404] |
| Ensembl ID | ENSRNOG00000002783 |
| Bio databases IDs | |
| Aliases | serpin family C member 1 |
| Synonyms | Antithrombin, Antithrombin 3, Antithrombin3 precursor, Antithrombin iii, ANTITHROMBIN III precursor, Antithrombin precursor, At-3, AT3D, At3 precursor, ATIII, ATIII precursor, ATIII-R2, ATIII-T1, ATIII-T2, serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1, serpin family C member 1, THPH7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Serpinc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protease binding
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- active site
- enzyme
- protein binding
- heparin binding
- identical protein binding
- Serpin (serine protease inhibitor)
- reactive serpin loop
Pathways
Biological processes and signaling networks where the Serpinc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- malignant neoplasm
- coronary disease
- disorder of coronary artery
- obesity
- acute ischemic stroke
- cardiovascular disorder
- non-insulin-dependent diabetes mellitus
- infertility condition
- osteoarthritis
role in cell
- apoptosis
- expression in
- migration
- proliferation
- aggregation
- accumulation
- response
- formation
- cellular infiltration by
- inhibition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- granules
- cytosol
- endoplasmic reticulum lumen
- extracellular matrix
- plasma
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Serpinc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of blood coagulation
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- serine-type endopeptidase inhibitor activity
- protein binding
- protease binding
- heparin binding