Tex15

Involved in transposable element silencing by piRNA-mediated DNA methylation. Acts upstream of or within with a positive effect on DNA methylation-dependent constitutive heterochromatin formation. Acts upstream of or within several processes, including male genitalia development; meiotic nuclear division; and regulation of double-strand break repair via homologous recombination. Located in cytoplasm and nucleus. Is expressed in meninges; oocyte; sensory organ; and spinal cord mantle layer. Human ortholog(s) of this gene implicated in spermatogenic failure 25. Orthologous to human TEX15 (testis expressed 15, meiosis and synapsis associated). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tex15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Tex15 gene, providing context for its role in the cell.