Tbxas1 Gene Summary [Rat]
Predicted to enable heme binding activity; hydroperoxy icosatetraenoate dehydratase activity; and thromboxane-A synthase activity. Involved in several processes, including intracellular chloride ion homeostasis; positive regulation of vasoconstriction; and response to ethanol. Predicted to be located in cytosol and endoplasmic reticulum membrane. Used to study acute necrotizing pancreatitis; artery disease (multiple); brain infarction; glomerulonephritis (multiple); and thrombosis. Biomarker of hydronephrosis. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome and cerebral infarction. Orthologous to human TBXAS1 (thromboxane A synthase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbxas1 |
| Official Name | thromboxane A synthase 1 [Source:RGD Symbol;Acc:3826] |
| Ensembl ID | ENSRNOG00000007918 |
| Bio databases IDs | |
| Aliases | thromboxane A synthase 1 |
| Synonyms | BDPLT14, CYP5, CYP5A1, GHOSAL, p450v, THAS, thromboxane A synthase 1, thromboxane A synthase 1, platelet, TS, TXAS, Txa Synthase, TXS, TX Synthase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tbxas1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- CH-CH group:NAD or NADP oxidoreductase
- thromboxane-A synthase
- hydro-lyase
- enzyme
- protein binding
- heme binding
Pathways
Biological processes and signaling networks where the Tbxas1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- acute lymphoblastic leukemia
- squamous cell cancer
- schizophrenia
- coronary artery disease
- ghosal hematodiaphyseal dysplasia syndrome
- diabetic nephropathy
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- drug-induced liver disease
- aortic valve calcification
regulates
- chloride
- progesterone
- eicosanoid
- prostanoid
- STAR
- prostaglandin h2
- prostaglandin
role in cell
- growth
- aggregation
- homeostasis in
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- basal compartment
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tbxas1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to ethanol
- cyclooxygenase pathway
- prostaglandin biosynthetic process
- icosanoid metabolic process
- positive regulation of vasoconstriction
- response to fatty acid
- cellular chloride ion homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- 12-hydroxyheptadecatrienoic acid synthase activity
- iron ion binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- monooxygenase activity
- heme binding
- thromboxane-A synthase activity