Eef1a2 Gene Summary [Rat]
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. [provided by RefSeq, Mar 2014]
Details
| Type | Protein Coding |
| Official Symbol | Eef1a2 |
| Official Name | eukaryotic translation elongation factor 1 alpha 2 [Source:RGD Symbol;Acc:3781] |
| Ensembl ID | ENSRNOG00000012477 |
| Bio databases IDs | |
| Aliases | eukaryotic translation elongation factor 1 alpha 2 |
| Synonyms | DEE33, Eef1a, EEF1AL, EF1A, EF1alpha, EF-1-alpha-2, EF-1-α-2, EIEE33, Elongation factor 1 alpha 2, Elongation factor 1 α 2, eukaryotic translation elongation factor 1 alpha 2, eukaryotic translation elongation factor 1 α 2, HS1, MRD38, Ps10, RATPS10, S1, STATIN, STN, STNL, wasted, wst |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eef1a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- translation elongation factor
- Elongation factor Tu C-terminal domain
- GTPase
- protein binding
- Elongation factor Tu domain 2
- translation regulator
- Domain III of Elongation factor (EF) Tu (EF-TU) and related proteins
- sulfate adenylyltransferase, large subunit
- Domain II of Elongation factor Tu (EF-Tu)-like proteins
- small GTP-binding protein domain
- translation elongation factor TU
- translation elongation factor EF-1 alpha
- Elongation factor Tu GTP binding domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- myocardial infarction
- epilepsy
- mental retardation
- autosomal dominant mental retardation type 38
- early infantile epileptic encephalopathy type 33
- renal cell cancer
- hereditary disorder
- complex neurodevelopmental disorder
- severe sepsis
role in cell
- apoptosis
- proliferation
- expression in
- phosphorylation in
- synthesis in
- molecular cleavage in
- migration
- morphology
- development
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- perinuclear region
- Nucleus
- Plasma Membrane
- endoplasmic reticulum membrane
- synapse
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eef1a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of apoptotic process
- translational elongation
- positive regulation of lipid kinase activity
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- synapse
- eukaryotic translation elongation factor 1 complex
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- protein binding
- translation elongation factor activity
- GTPase activity
- translation factor activity, nucleic acid binding