Cacna2d4 Gene Summary [Rat]
Predicted to enable voltage-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and detection of light stimulus involved in visual perception. Predicted to be part of voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in retinal cone dystrophy 4. Orthologous to human CACNA2D4 (calcium voltage-gated channel auxiliary subunit alpha2delta 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cacna2d4 |
| Official Name | calcium voltage-gated channel auxiliary subunit alpha2delta 4 [Source:RGD Symbol;Acc:1562038] |
| Ensembl ID | ENSRNOG00000008031 |
| Bio databases IDs | |
| Aliases | calcium voltage-gated channel auxiliary subunit alpha2delta 4 |
| Synonyms | 5730412N02RIK, BE686333, calcium channel, voltage-dependent, alpha 2/delta subunit 4, calcium channel, voltage-dependent, α 2/δ subunit 4, calcium voltage-gated channel auxiliary subunit alpha2delta 4, RCD4, RGD1562038 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cacna2d4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated calcium channel
- Neuronal voltage-dependent calcium channel alpha 2acd
- von Willebrand factor (vWF) type A domain
- vWFA
- von Willebrand factor type A domain
- Sensor domains of Histidine Kinase receptors
- VWA N-terminal
- ion channel
Pathways
Biological processes and signaling networks where the Cacna2d4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Androgen Signaling
- Calcium Signaling
- Cardiac Hypertrophy Signaling
- Cardiac β-adrenergic Signaling
- CCR5 Signaling in Macrophages
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- CREB Signaling in Neurons
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Estrogen Receptor Signaling
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Maturity Onset Diabetes of Young (MODY) Signaling
- Mitochondrial Dysfunction
- nNOS Signaling in Skeletal Muscle Cells
- Serotonin Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- pregabalin
regulates
- Ca2+
disease
- non-insulin-dependent diabetes mellitus
- HIV infection
- human immunodeficiency virus I infection
- diabetes mellitus
- cancer
- pain
- neuropathy
- neuropathic pain
- generalized anxiety disorder
- peripheral mononeuropathic pain
role in cell
- neural network activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cacna2d4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of light stimulus involved in visual perception
- calcium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- voltage-gated calcium channel complex
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- voltage-gated calcium channel activity