Alox5 Gene Summary [Rat]
Predicted to enable arachidonate 5-lipoxygenase activity and iron ion binding activity. Involved in several processes, including positive regulation of cytochrome-c oxidase activity; positive regulation of vasoconstriction; and response to hyperoxia. Located in dendrite; nuclear envelope; and sarcolemma. Used to study several diseases, including brain ischemia; hypertension (multiple); pleurisy; portal hypertension; and pulmonary edema. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alox5 |
| Official Name | arachidonate 5-lipoxygenase [Source:RGD Symbol;Acc:2096] |
| Ensembl ID | ENSRNOG00000012972 |
| Bio databases IDs | |
| Aliases | arachidonate 5-lipoxygenase |
| Synonyms | 5-LIPOXYGENASE, 5-LO, 5-LOX, 5LPG, 5LX, AI850497, Arachidonate-5-lipoxygenase, F730011J02, LOG5, LOX5A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Alox5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arachidonate 5-lipoxygenase
- catalytic domain
- oxidoreductase
- iron ion binding
- enzyme
- protein binding
- phospholipid binding domain
- Lipoxygenase homology 2 (beta barrel) domain
- proline rich domain
- Sh3 domain binding motif
- C2-like domain
- beta barrel
- PLAT
- single donor oxygen oxidoreductase
Pathways
Biological processes and signaling networks where the Alox5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HIV infection
- infection
- neoplasia
- metastasis
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
role in cell
- apoptosis
- expression in
- phosphorylation in
- migration
- cellular infiltration by
- activation
- differentiation
- permeability
- function
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- intracellular space
- perinuclear region
- Nucleus
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- perinuclear space
- outer nuclear membrane
- nuclear envelope
- nuclear matrix
- sarcolemma
- cytoplasmic vesicles
- perikaryon
- dendrites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Alox5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of wound healing
- negative regulation of angiogenesis
- long-chain fatty acid biosynthetic process
- leukotriene metabolic process
- negative regulation of inflammatory response
- lipid oxidation
- negative regulation of vascular wound healing
- regulation of cytokine production involved in inflammatory response
- regulation of fat cell differentiation
- leukotriene production involved in inflammatory response
- leukocyte chemotaxis involved in inflammatory response
- regulation of cellular response to oxidative stress
- regulation of insulin secretion
- leukocyte migration involved in inflammatory response
- leukotriene biosynthetic process
- lipoxygenase pathway
- humoral immune response
- glucose homeostasis
- regulation of inflammatory response
- negative regulation of endothelial cell proliferation
- arachidonic acid metabolic process
- positive regulation of bone mineralization
- lipoxin biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear membrane
- extracellular space
- perinuclear region of cytoplasm
- nuclear matrix
- cytosol
- secretory granule lumen
- extracellular region
- nuclear envelope lumen
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- iron ion binding
- arachidonate 12-lipoxygenase activity
- arachidonate 5-lipoxygenase activity
- hydrolase activity