Tox2 Gene Summary [Rat]
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in female gonad development; positive regulation of transcription by RNA polymerase II; and response to gonadotropin. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human TOX2 (TOX high mobility group box family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tox2 |
| Official Name | TOX high mobility group box family member 2 [Source:RGD Symbol;Acc:735184] |
| Ensembl ID | ENSRNOG00000008146 |
| Bio databases IDs | |
| Aliases | TOX high mobility group box family member 2 |
| Synonyms | AI851523, AV026525, C20orf100, dJ1108D11.2, dJ495O3.1, GCX-1, RxHMG1, TOX high mobility group box family member 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tox2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lysine rich domain
- transcription regulator
- transcription co-activator
- serine-rich region
- high mobility group (HMG)-box domain superfamily
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- transcription factor binding
- protein binding
- proline rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- colorectal adenoma
- colorectal adenoma formation
- organismal death
- stuttering
- multiple sclerosis
- natural killer/T-cell lymphoma
- T-cell non-Hodgkin disease
- natural killer cell neoplasia
role in cell
- expression in
- maturation
- growth
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tox2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- transcription coactivator activity