Ptp4a3 Gene Summary [Rat]
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in several processes, including endothelial cell migration; positive regulation of establishment of protein localization; and positive regulation of non-canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of vascular permeability; and regulation of vascular endothelial growth factor signaling pathway. Predicted to be active in cytoplasm and nucleus. Orthologous to human PTP4A3 (protein tyrosine phosphatase 4A3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptp4a3 |
| Official Name | protein tyrosine phosphatase 4A3 [Source:RGD Symbol;Acc:1308687] |
| Ensembl ID | ENSRNOG00000007628 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase 4A3 |
| Synonyms | pPtp4a3, PRL-3, PRL-CAAX3, PRL-R, protein tyrosine phosphatase 4A3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptp4a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- protein-tyrosine-phoshatase
- phosphatase
- protein binding
- PTP_DSP_cys
- prenylation site
- phosphatase domain
- Protein tyrosine phosphatase, catalytic domain motif
Pathways
Biological processes and signaling networks where the Ptp4a3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- metastasis
- papillary thyroid carcinoma
- chronic lymphocytic leukemia
- non-insulin-dependent diabetes mellitus
- autosomal dominant polycystic kidney disease
- tumorigenesis
- advanced cancer
- colorectal neoplasm
role in cell
- growth
- migration
- proliferation
- invasion by
- phosphorylation in
- transactivation in
- activation in
- quantity
- expression in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- Nucleus
- endosomes
- metaphase plate
- nuclear envelope
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptp4a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Notch signaling pathway
- regulation of transcription, DNA-dependent
- endothelial cell migration
- regulation of vascular endothelial growth factor signaling pathway
- positive regulation of vascular permeability
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine phosphatase activity
- prenylated protein tyrosine phosphatase activity