Washc4 Gene Summary [Rat]

Predicted to be involved in endosomal transport and endosome organization. Predicted to act upstream of or within several processes, including endolysosomal toll-like receptor signaling pathway; neuromuscular process; and regulation of protein complex stability. Predicted to be located in nucleoplasm. Predicted to be part of BLOC-1 complex and WASH complex. Predicted to be active in endosome. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 43. Orthologous to human WASHC4 (WASH complex subunit 4). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Washc4
Official Name
WASH complex subunit 4 [Source:RGD Symbol;Acc:1309995]
Ensembl ID
ENSRNOG00000008331
Bio databases IDs NCBI: 314690 Ensembl: ENSRNOG00000008331
Aliases WASH complex subunit 4
Synonyms A230046K03Rik, KIAA1033, mKIAA1033, MRT43, RGD1309995, SWIP, WASH complex subunit 4
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Washc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • WASH complex subunit 4, N-terminal
  • WASH complex subunit 7, C-terminal
  • WASH complex subunit 7
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
  • Influenza A virus (A/Udon/307/72 (H3N2))
disease
  • autosomal recessive mental retardation type 43
  • autosomal recessive mental retardation
  • mental retardation
role in cell
  • transport
  • organization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • endosomes
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Washc4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • endosome organization
  • protein transport
  • endosomal transport
  • regulation of Arp2/3 complex-mediated actin nucleation

Cellular Component

Where in the cell the gene product is active
  • early endosome membrane
  • BLOC-1 complex
  • endosome
  • WASH complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.