Il17f Gene Summary [Rat]
Predicted to enable cytokine binding activity; protein dimerization activity; and signaling receptor binding activity. Predicted to be involved in several processes, including defense response to bacterium; interleukin-17-mediated signaling pathway; and regulation of cytokine production. Predicted to act upstream of or within positive regulation of cytokine production involved in inflammatory response and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis. Orthologous to human IL17F (interleukin 17F). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il17f |
| Official Name | interleukin 17F [Source:RGD Symbol;Acc:1311398] |
| Ensembl ID | ENSRNOG00000012509 |
| Bio databases IDs | |
| Aliases | interleukin 17F |
| Synonyms | C87042, CANDF6, IL17A, interleukin 17F, ML-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il17f often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- cytokine binding
- protein homodimerization
- protein binding
- Interleukin-17
- cytokine
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Il17f gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Airway Inflammation in Asthma
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Erythropoietin Signaling
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-17 Signaling
- RAR Activation
- Role of Cytokines in Mediating Communication between Immune Cells
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- T Helper Cell Differentiation
- Th17 Activation Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plaque psoriasis
- hyperplasia
- hidradenitis suppurativa
- psoriatic arthritis
- ankylosing spondylitis
- acanthosis
- psoriasis
- adult-onset psoriatic arthritis
- inflammatory bowel disease
- neutrophilia
role in cell
- expression in
- phosphorylation in
- number
- proliferation
- production in
- maturation
- activation
- survival
- recruitment
- adipogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- intracellular space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il17f gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- defense response to Gram-negative bacterium
- positive regulation of chemokine (C-X-C motif) ligand 1 production
- adaptive immune response
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of antimicrobial peptide production
- inflammatory response
- innate immune response
- regulation of interleukin-2 production
- regulation of interleukin-6 production
- positive regulation of lymphotoxin A production
- regulation of granulocyte macrophage colony-stimulating factor production
- positive regulation of interleukin-6 production
- regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of cytokine production
- defense response to Gram-positive bacterium
- cartilage development
- regulation of interleukin-8 production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- cytokine activity
- cytokine binding
- cytokine receptor binding