Zfyve1 Gene Summary [Rat]
Predicted to enable phosphatidylinositol binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in several processes, including cellular response to starvation; lipid droplet formation; and positive regulation by host of viral genome replication. Predicted to be located in several cellular components, including autophagosome; mitochondria-associated endoplasmic reticulum membrane contact site; and omegasome. Predicted to be extrinsic component of omegasome membrane. Predicted to be active in lipid droplet. Orthologous to human ZFYVE1 (zinc finger FYVE-type containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfyve1 |
| Official Name | zinc finger FYVE-type containing 1 [Source:RGD Symbol;Acc:1307795] |
| Ensembl ID | ENSRNOG00000008614 |
| Bio databases IDs | |
| Aliases | zinc finger FYVE-type containing 1 |
| Synonyms | DFCP1, G630053K23, mKIAA1589, PPP1R172, SR3, TAFF1, zinc finger, FYVE domain containing 1, zinc finger FYVE-type containing 1, ZNFN2A1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zfyve1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- B-box-type zinc finger superfamily
- binding protein
- phosphatidylinositol-3,4,5-triphosphate binding
- Protein present in Fab1, YOTB, Vac1, and EEA1
- ER targeting sequence
- PHD finger superfamily
- protein binding
- phosphatidylinositol binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- pervasive developmental disorder
- metabolic syndrome X
- kidney carcinoma
- renal cancer
- wheeze
regulates
- ZFYVE1
- phosphatidylinositol-3-phosphate
role in cell
- response
- formation
- morphology
- formation in
- macroautophagy in
- dispersal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- omegasome
- perinuclear region
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- lipid droplets
- endoplasmic reticulum membrane
- Golgi stacks
- autophagic vacuoles
- cytoplasmic vesicles
- Golgi cisternae
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zfyve1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to starvation
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- pre-autophagosomal structure
- mitochondrion
- membrane
- ER-mitochondrion membrane contact site
- Golgi apparatus
- endoplasmic reticulum
- Golgi stack
- autophagic vacuole
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- zinc ion binding
- protein binding
- phosphatidylinositol-3-phosphate binding
- phosphatidylinositol-3,4-bisphosphate binding
- 1-phosphatidylinositol binding