Aldh7a1 Gene Summary [Rat]
Predicted to enable betaine-aldehyde dehydrogenase (NAD+) activity and identical protein binding activity. Predicted to be involved in glycine betaine biosynthetic process from choline. Predicted to be located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in early-onset vitamin B6-dependent epilepsy 4. Orthologous to human ALDH7A1 (aldehyde dehydrogenase 7 family member A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aldh7a1 |
| Official Name | aldehyde dehydrogenase 7 family, member A1 [Source:RGD Symbol;Acc:1308614] |
| Ensembl ID | ENSRNOG00000014645 |
| Bio databases IDs | |
| Aliases | aldehyde dehydrogenase 7 family, member A1 |
| Synonyms | aldehyde dehydrogenase 7 family member A1, aldehyde dehydrogenase 7 family, member A1, Aldehyde dehydrogenase family 7 member a1, aldehyde dehydrogenase family 7, member A1, antiquitin, ATQ1, D18Wsu181e, EPD, EPEO4, PDE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aldh7a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldehyde dehydrogenase family
- betaine-aldehyde dehydrogenase
- L-aminoadipate-semialdehyde dehydrogenase
- aldehyde dehydrogenase (NAD)
- enzyme
- protein binding
- identical protein binding
- methylmalonic acid semialdehyde dehydrogenase
- aldehyde or oxo group:NAD or NADP oxidoreductase
- delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain)
- NAD(P)+-dependent aldehyde dehydrogenase superfamily
Pathways
Biological processes and signaling networks where the Aldh7a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- epithelial cancer
- pyridoxine-dependent epilepsy
- early-onset vitamin B6-dependent epilepsy type 4
- coronary artery disease
- hereditary disorder
- osteoporosis
- prostate cancer
- early infantile epileptic encephalopathy type 13
- seizures
regulates
- norepinephrine
- choline
- vitamin
- amino acids
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aldh7a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- choline catabolic process
- sensory perception of sound
- cellular aldehyde metabolic process
- glycine betaine biosynthetic process from choline
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- mitochondrial matrix
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- aldehyde dehydrogenase (NAD) activity
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
- identical protein binding
- betaine-aldehyde dehydrogenase activity
- protein binding
- L-aminoadipate-semialdehyde dehydrogenase activity