Lsm3 Gene Summary [Rat]
Predicted to enable U6 snRNA 3'-end binding activity. Predicted to be involved in P-body assembly and mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of Lsm1-7-Pat1 complex; Lsm2-8 complex; and nucleus. Predicted to be active in P-body. Orthologous to human LSM3 (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lsm3 |
| Official Name | LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:RGD Symbol;Acc:1305971] |
| Ensembl ID | ENSRNOG00000008733 |
| Bio databases IDs | |
| Aliases | LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated |
| Synonyms | 1010001J12Rik, 2610005D18RIK, 6030401D18RIK, LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated, SMX4, USS2, YLR438C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lsm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sm and related proteins
- U6 snRNA 3' end binding
- protein binding
Pathways
Biological processes and signaling networks where the Lsm3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- Cytoplasm
- cytosol
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lsm3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic mRNA processing body assembly
- mRNA processing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- precatalytic spliceosome
- U4/U6 x U5 tri-snRNP complex
- cytosol
- cytoplasmic mRNA processing body
- U2-type precatalytic spliceosome
- U6 snRNP
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- U6 snRNA 3'-end binding