Sf3b2 Gene Summary [Rat]
Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP and spliceosomal complex. Human ortholog(s) of this gene implicated in Goldenhar syndrome. Orthologous to human SF3B2 (splicing factor 3b subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sf3b2 |
| Official Name | splicing factor 3b, subunit 2 [Source:RGD Symbol;Acc:1307159] |
| Ensembl ID | ENSRNOG00000020412 |
| Bio databases IDs | |
| Aliases | splicing factor 3b, subunit 2 |
| Synonyms | 2610311M13Rik, 2810441F20Rik, B230398H18Rik, CFM, Cus1, HFM, SAP145, SF3b1, SF3B145, SF3b150, splicing factor 3b subunit 2, splicing factor 3b, subunit 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sf3b2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SAP motif
- PSP
- SAP domain
- protein binding
- CUS1 domain
- Domain of unknown function (DUF382)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- craniofacial microsomia type 1
- glioblastoma
- rheumatoid arthritis
- metabolic syndrome X
- astrocytoma
- glioma formation
- glioblastoma cancer
- infection by HIV-1
regulates
role in cell
- migration
- growth
- invasion by
- cell death
- focus formation
- splicing by
- focus formation in
- colony formation
- alternative splicing in
- homologous recombination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sf3b2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- mRNA processing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- U12-type spliceosomal complex
- catalytic step 2 spliceosome
- nuclear speck
- precatalytic spliceosome
- spliceosomal complex
- U2-type spliceosomal complex
- U2-type precatalytic spliceosome
- U2 snRNP
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding