Lsm2 Gene Summary [Rat]
Predicted to enable protein kinase binding activity and small GTPase binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA catabolic process and spliceosomal tri-snRNP complex assembly. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of Lsm2-8 complex; U4/U6 x U5 tri-snRNP complex; and spliceosomal complex. Orthologous to human LSM2 (LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lsm2 |
| Official Name | LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:RGD Symbol;Acc:1598536] |
| Ensembl ID | ENSRNOG00000048725 |
| Bio databases IDs | |
| Aliases | LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated |
| Synonyms | C6orf28, D17H6S56E-2, Dmapl, DMPKAP, G7B, LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated, Sm-X5, snRNP, YBL026W |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lsm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sm and related proteins
- protein kinase binding
- enzyme binding
- protein binding
Pathways
Biological processes and signaling networks where the Lsm2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- cutaneous melanoma cancer
- inguinal hernia
- organismal death
- lymphomagenesis
- pneumonia
- lymphoma
regulates
- snRNP
role in cell
- proliferation
- migration
- invasion by
- splicing by
- homologous recombination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- Cytoplasm
- cytosol
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lsm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA catabolic process
- assembly of spliceosomal tri-snRNP
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- cytoplasm
- precatalytic spliceosome
- U4/U6 x U5 tri-snRNP complex
- cytosol
- cytoplasmic mRNA processing body
- U2-type precatalytic spliceosome
- U6 snRNP
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- U6 snRNA binding
- protein binding
- RNA binding
- small GTPase binding