Farp1 Gene Summary [Rat]
Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including dendrite morphogenesis; retrograde trans-synaptic signaling by trans-synaptic protein complex; and synapse organization. Located in cytoplasmic side of plasma membrane; cytosol; and dendrite. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic membrane. Orthologous to human FARP1 (FERM, ARH/RhoGEF and pleckstrin domain protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Farp1 |
| Official Name | FERM, ARH/RhoGEF and pleckstrin domain protein 1 [Source:RGD Symbol;Acc:1305346] |
| Ensembl ID | ENSRNOG00000011203 |
| Bio databases IDs | |
| Aliases | FERM, ARH/RhoGEF and pleckstrin domain protein 1 |
| Synonyms | CDEP, FARP1-IT1, FERM, ARH/RhoGEF and pleckstrin domain protein 1, GLCC1, LOC100361560, PLEKHC2, PPP1R75 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Farp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM central domain
- Band 4.1 homologues
- enzyme binding
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
- FERM N-terminal domain
- FERM adjacent (FA)
- RhoGEF
- guanyl-nucleotide exchange factor
- Ubl1_cv_Nsp3_N-like
- PH domain
- FERM domain B-lobe
- FERM C-terminal PH-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Alzheimer disease
- coronary artery disease
- migraines
- drug abuse
- organismal death
- anxiety disorder
- Kawasaki disease
- secondary thrombocytopenia
- nonalcoholic fatty liver disease
role in cell
- expression in
- quantity
- degradation in
- binding in
- migration
- assembly
- complexity
- morphogenesis
- arborization in
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cytoskeleton
- Cytoplasm
- cytosol
- cytoplasmic face of plasma membrane
- dendritic spines
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Farp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Rac protein signal transduction
- synapse assembly
- enzyme linked receptor protein signaling pathway
- dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoskeleton
- dendritic spine
- cytosol
- filopodium
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding
- cytoskeletal protein binding