LSM3 Gene Summary [Human]
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
Details
| Type | Protein Coding |
| Official Symbol | LSM3 |
| Official Name | LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:17874] |
| Ensembl ID | ENSG00000170860 |
| Bio databases IDs | |
| Aliases | LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated |
| Synonyms | 1010001J12Rik, 2610005D18RIK, 6030401D18RIK, LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated, SMX4, USS2, YLR438C |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LSM3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sm and related proteins
- U6 snRNA 3' end binding
- protein binding
Pathways
Biological processes and signaling networks where the LSM3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- Cytoplasm
- cytosol
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LSM3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic mRNA processing body assembly
- mRNA processing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- precatalytic spliceosome
- U4/U6 x U5 tri-snRNP complex
- cytosol
- cytoplasmic mRNA processing body
- U2-type precatalytic spliceosome
- U6 snRNP
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- U6 snRNA 3'-end binding