Epn1 Gene Summary [Rat]
Enables clathrin adaptor activity and transmembrane transporter binding activity. Involved in several processes, including clathrin coat assembly; membrane fission; and positive regulation of clathrin coat assembly. Located in cytosol; postsynaptic membrane; and presynaptic membrane. Is active in Schaffer collateral - CA1 synapse and postsynapse. Biomarker of middle cerebral artery infarction. Orthologous to human EPN1 (epsin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epn1 |
| Official Name | Epsin 1 [Source:RGD Symbol;Acc:619772] |
| Ensembl ID | ENSRNOG00000015753 |
| Bio databases IDs | |
| Aliases | Epsin 1 |
| Synonyms | EPSIN, Epsin 1, Ibp1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Epn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin binding domain
- alpha helix
- DPW domain
- protein binding activity, bridging
- NPF motif
- ion channel binding
- VHS, ENTH and ANTH domain superfamily
- protein binding
- ENTH domain
Pathways
Biological processes and signaling networks where the Epn1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- weight gain
- insomnia
- breast adenocarcinoma
- infection by Dengue virus 2
role in cell
- internalization in
- morphology
- remodeling
- remodeling in
- assembly
- outgrowth
- Clathrin mediated endocytosis by
- fission
- endocytosis
- receptor-mediated endocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- presynaptic regions
- postsynaptic region
- Nucleus
- Golgi Apparatus
- endocytic nucleation point
- cytosol
- presynaptic membrane
- postsynaptic membrane
- trans Golgi network
- synaptic vesicles
- nerve ending
- synapse
- clathrin-coated pits
- clathrin-coated vesicles
- synaptosomal fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Epn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Notch signaling pathway
- in utero embryonic development
- female pregnancy
- embryonic organ development
- endocytosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- endosome
- coated pit
- cytosol
- clathrin vesicle coat
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- clathrin binding
- phospholipid binding