Ap1b1 Gene Summary [Rat]
Enables protein serine/threonine kinase binding activity. Involved in clathrin coat assembly. Predicted to be located in Golgi apparatus and cytosol. Predicted to be part of clathrin coat. Predicted to be active in synaptic vesicle. Orthologous to human AP1B1 (adaptor related protein complex 1 subunit beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ap1b1 |
| Official Name | adaptor related protein complex 1 subunit beta 1 [Source:RGD Symbol;Acc:2064] |
| Ensembl ID | ENSRNOG00000008786 |
| Bio databases IDs | |
| Aliases | adaptor related protein complex 1 subunit beta 1 |
| Synonyms | adaptor protein complex AP-1, beta 1 subunit, adaptor protein complex AP-1, β 1 subunit, adaptor related protein complex 1 subunit beta 1, adaptor related protein complex 1 subunit β 1, ADTB1, AP105A, b2b1660Clo, BAM22, CLAPB2, CLATHRIN beta2 subunit, KIDAR, β 1 Adaptin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ap1b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- appendage domain
- non-SMC mitotic condensation complex subunit 1
- protein kinase binding
- Adaptin C-terminal domain
- ear domain
- hinge domain
- Adaptin N terminal region
- protein binding
- HEAT repeats
- trunk domain
- Beta2-adaptin appendage, C-terminal sub-domain
Pathways
Biological processes and signaling networks where the Ap1b1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive keratitis ichthyosis and deafness syndrome
- hemorrhoid
- Parkinson disease
- congenital heart disease
- infection by Dengue virus 2
role in cell
- assembly
- packaging in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- Nucleus
- Golgi Apparatus
- Mitochondria
- cytosol
- Golgi membrane
- trans Golgi network
- lysosome membrane
- synaptic vesicles
- clathrin-coated vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ap1b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- platelet dense granule organization
- heart development
- vesicle-mediated transport
- kidney development
- intracellular protein transport
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- early endosome
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- AP-1 adaptor complex
- cytosol
- Golgi membrane
- Golgi apparatus
- lysosomal membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- clathrin binding