Gjb2 Gene Summary [Rat]
Enables gap junction channel activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to glucagon stimulus; and decidualization. Located in several cellular components, including astrocyte projection; gap junction; and lateral plasma membrane. Used to study hepatocellular carcinoma and lung adenocarcinoma. Biomarker of autoimmune thyroiditis; extrahepatic cholestasis; ischemia; sensorineural hearing loss; and urethral obstruction. Human ortholog(s) of this gene implicated in Bart-Pumphrey syndrome; Vohwinkel syndrome; autosomal dominant keratitis-ichthyosis-deafness syndrome; nonsyndromic deafness (multiple); and palmoplantar keratoderma-deafness syndrome. Orthologous to human GJB2 (gap junction protein beta 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gjb2 |
| Official Name | gap junction protein, beta 2 [Source:RGD Symbol;Acc:728891] |
| Ensembl ID | ENSRNOG00000008855 |
| Bio databases IDs | |
| Aliases | gap junction protein, beta 2 |
| Synonyms | BAPS, Cnx26, CX26, CXN-26, Cxne, DFNA3, DFNA3A, DFNB1, DFNB1A, gap junction protein beta 2, gap junction protein, beta 2, gap junction protein β 2, gap junction protein, β 2, HID, KID, NSRD1, PPK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gjb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Connexin homologues
- Gap junction channel protein cysteine-rich domain
- transmembrane domain
- calcium ion binding
- protein binding
- identical protein binding
- transporter
- Connexin
- gap-junction forming channel
Pathways
Biological processes and signaling networks where the Gjb2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- familial nonsyndromic hearing impairment
- autosomal dominant deafness type 3A
- autosomal recessive deafness type 1A
- autosomal dominant keratitis ichthyosis and deafness syndrome
- autosomal recessive deafness
- plaque psoriasis
- sensorineural hearing loss
- diabetes mellitus
- GJB2-related disorder
role in cell
- growth
- loss
- cell death
- apoptosis
- cellular infiltration by
- formation
- monorden sensitivity
- density
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell junction
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- vesicles
- lysosome
- cell-cell contacts
- connexons
- ER-to-Golgi intermediate compartment
- lateral plasma membrane
- perinucleolar compartments
- gap junction plaques
- gap junctions
- perikaryon
- astrocyte projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gjb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- inner ear development
- response to progesterone stimulus
- cell-cell signaling
- decidualization
- sensory perception of sound
- response to retinoic acid
- response to ischemia
- cellular response to glucagon stimulus
- cell communication by electrical coupling
- response to estradiol stimulus
- gap junction assembly
- cellular response to oxidative stress
- response to lipopolysaccharide
- cellular response to dexamethasone stimulus
Cellular Component
Where in the cell the gene product is active
- gap junction
- lateral plasma membrane
- connexon complex
- perinuclear region of cytoplasm
- cell body
- endoplasmic reticulum-Golgi intermediate compartment
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- calcium ion binding
- gap junction channel activity