Pou2f3 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in epidermis development and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nuclear lumen; and plasma membrane. Predicted to be part of transcription regulator complex. Orthologous to human POU2F3 (POU class 2 homeobox 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pou2f3 |
| Official Name | POU class 2 homeobox 3 [Source:RGD Symbol;Acc:621691] |
| Ensembl ID | ENSRNOG00000009118 |
| Bio databases IDs | |
| Aliases | POU class 2 homeobox 3 |
| Synonyms | Epoc-1, OCT-11, Oct-11a, OTF-11, PLA-1, POU class 2 homeobox 3, POU domain, class 2, transcription factor 3, Skin, Skin-1a, Skn-1a, Skn-li |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pou2f3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- Pou domain - N-terminal to homeobox domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- POU specific domain
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cutaneous melanoma
- psoriasis
- pernicious anemia
- cutaneous melanoma cancer
role in cell
- growth
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- nucleoli
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pou2f3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation by host of viral transcription
- keratinocyte differentiation
- wound healing
- epidermis development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- nuclear body
- cytosol
- nucleolus
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity