Krt10 Gene Summary [Rat]
Predicted to enable cytoskeletal protein binding activity and protein heterodimerization activity. Predicted to be a structural constituent of skin epidermis. Predicted to be involved in several processes, including intermediate filament organization; peptide cross-linking; and protein heterotetramerization. Predicted to act upstream of or within cellular response to calcium ion; keratinocyte development; and stem cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in cornified envelope and keratin filament. Human ortholog(s) of this gene implicated in epidermolytic hyperkeratosis and epidermolytic hyperkeratosis 2. Orthologous to human KRT10 (keratin 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt10 |
| Official Name | keratin 10 [Source:RGD Symbol;Acc:1359092] |
| Ensembl ID | ENSRNOG00000030170 |
| Bio databases IDs | |
| Aliases | keratin 10 |
| Synonyms | BCIE, BIE, CK10, D130054E02RIK, EHK, EHK2, EHK2A, EHK2B, IHL, K10, K1C1, Ka10, Ker59, Keratin 10, Keratin 1-10, KPP, Krt-1.10, KRT1-10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Krt10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoskeletal protein binding
- structural constituent of epidermis
- protein binding
- Intermediate filament protein
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Krt10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- benign neoplasia
- autosomal recessive epidermolytic hyperkeratosis type 2B
- Lambert type ichthyosis hystrix
- atopic dermatitis
- hyperkeratosis
- autosomal dominant epidermolytic hyperkeratosis type 2A
- hypoplasia
- clear cell acanthoma
role in cell
- cellular infiltration by
- differentiation
- proliferation
- development
- cell cycle progression
- formation
- growth
- size
- response by
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cornified envelope
- cytoskeleton
- Mitochondria
- intermediate filaments
- cytosol
- nucleoli
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Krt10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- keratinocyte differentiation
- positive regulation of epidermis development
- epidermis development
- peptide cross-linking
- protein heterotetramerization
- intermediate filament organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cornified envelope
- cytoskeleton
- keratin filament
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- intermediate filament
- cell surface
Molecular Function
What the gene product does at the molecular level
- structural constituent of epidermis
- protein binding
- protein heterodimerization activity