Pou2f3 Gene Summary [Mouse]
Enables identical protein binding activity and sequence-specific DNA binding activity. Involved in cell differentiation. Acts upstream of or within keratinocyte differentiation; positive regulation of transcription by RNA polymerase II; and wound healing. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; gut; skin; and thymus. Orthologous to human POU2F3 (POU class 2 homeobox 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pou2f3 |
| Official Name | POU domain, class 2, transcription factor 3 [Source:MGI Symbol;Acc:MGI:102565] |
| Ensembl ID | ENSMUSG00000032015 |
| Bio databases IDs | |
| Aliases | POU domain, class 2, transcription factor 3 |
| Synonyms | Epoc-1, OCT-11, Oct-11a, OTF-11, PLA-1, POU class 2 homeobox 3, POU domain, class 2, transcription factor 3, Skin, Skin-1a, Skn-1a, Skn-li |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pou2f3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- Pou domain - N-terminal to homeobox domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- POU specific domain
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cutaneous melanoma
- psoriasis
- pernicious anemia
- cutaneous melanoma cancer
role in cell
- growth
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- nucleoli
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pou2f3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation by host of viral transcription
- keratinocyte differentiation
- wound healing
- epidermis development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- nuclear body
- cytosol
- nucleolus
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity