Cdc27 Gene Summary [Rat]
Predicted to enable protein phosphatase binding activity. Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; metaphase/anaphase transition of mitotic cell cycle; and protein polyubiquitination. Predicted to act upstream of or within neuron projection development. Predicted to be located in centrosome; mitotic spindle; and nucleoplasm. Predicted to be part of anaphase-promoting complex. Predicted to be active in cytoplasm. Orthologous to human CDC27 (cell division cycle 27). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdc27 |
| Official Name | cell division cycle 27 [Source:RGD Symbol;Acc:1304921] |
| Ensembl ID | ENSRNOG00000005904 |
| Bio databases IDs | |
| Aliases | cell division cycle 27 |
| Synonyms | AI452358, ANAPC3, APC3, CDC27Hs, cell division cycle 27, D0S1430E, D17S978E, H-NUC, NUC2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdc27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR repeat
- protein phosphatase binding
- Tetratricopeptide repeats
- protein binding
- tetratricopeptide repeat
- Anaphase-promoting complex, cyclosome, subunit 3
Pathways
Biological processes and signaling networks where the Cdc27 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- Alzheimer disease
- non-insulin-dependent diabetes mellitus
- essential hypertension
- major depression
- acute coronary syndrome
- sporadic systemic lupus erythematosus
- erythema nodosum
- Waldenström macroglobulinemia
- familial systemic lupus erythematosus
role in cell
- expression in
- replication in
- morphogenesis
- cell cycle progression
- biogenesis by
- degradation in
- escape
- biogenesis in
- contact growth inhibition
- biogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- Cytoplasm
- centrosome
- centriole
- cytosol
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdc27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- regulation of meiotic cell cycle
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- mitotic metaphase/anaphase transition
- regulation of mitotic cell cycle
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- mitotic spindle
- cytoplasm
- anaphase-promoting complex
- spindle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein phosphatase binding
- protein binding