Arhgap24 Gene Summary [Rat]
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of Rac protein signal transduction; negative regulation of ruffle assembly; and wound healing, spreading of epidermal cells. Predicted to act upstream of or within activation of GTPase activity. Predicted to be located in several cellular components, including adherens junction; cell projection; and cytoskeleton. Predicted to be active in focal adhesion. Orthologous to human ARHGAP24 (Rho GTPase activating protein 24). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap24 |
| Official Name | Rho GTPase activating protein 24 [Source:RGD Symbol;Acc:1306669] |
| Ensembl ID | ENSRNOG00000056944 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 24 |
| Synonyms | 0610025G21Rik, DR-NR#2, FILGAP, p73RhoGAP, RC-GAP72, Rho GTPase activating protein 24 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arhgap24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- PH domain
- GTPase activator
- protein binding
- GTPase Activating Protein domain
- Pleckstrin homology-like domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
Pathways
Biological processes and signaling networks where the Arhgap24 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- COVID-19
- asthma
- Alzheimer disease
- dementia
- hypertension
- hepatocellular carcinoma
- liver cancer
- non-insulin-dependent diabetes mellitus
- renal clear cell adenocarcinoma
regulates
- p70 S6k
- AKT
- RAS homolog
- ITGB4
- RAC
role in cell
- phosphorylation in
- migration
- expression in
- formation
- proliferation
- growth
- morphology
- disruption
- invasion by
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- Nucleus
- actin stress fibers
- anchoring junction
- cell-cell adherens junctions
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arhgap24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- angiogenesis
- negative regulation of Rac protein signal transduction
- cell differentiation
- negative regulation of ruffle assembly
- wound healing, spreading of epidermal cells
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cytoskeleton
- focal adhesion
- cytoplasm
- cell projection
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity