Rab6b Gene Summary [Rat]
Predicted to enable GTPase activity and myosin V binding activity. Predicted to be involved in several processes, including Golgi vesicle transport; protein localization to Golgi membrane; and retrograde transport, endosome to Golgi. Is active in presynapse. Orthologous to human RAB6B (RAB6B, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab6b |
| Official Name | RAB6B, member RAS oncogene family [Source:RGD Symbol;Acc:1309958] |
| Ensembl ID | ENSRNOG00000009198 |
| Bio databases IDs | |
| Aliases | RAB6B, member RAS oncogene family |
| Synonyms | 9630015C03, C330006L04Rik, D9BWG0185E, RAB6B, member RAS oncogene family |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rab6b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- myosin binding
- ADP-ribosylation factor family
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
regulates
- VPS13B
role in cell
- formation
- fragmentation
- organization
- replication in
- fragmentation in
- morphogenesis
- entrance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- presynaptic regions
- perinuclear region
- basal bodies
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- Golgi membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rab6b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retrograde vesicle-mediated transport, Golgi to ER
- neuron projection development
- Golgi organization
- intra-Golgi vesicle-mediated transport
- intracellular protein transport
- retrograde transport, endosome to Golgi
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle
- cytosol
- endomembrane system
- Golgi membrane
- Golgi apparatus
- endoplasmic reticulum-Golgi intermediate compartment
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- myosin V binding