Acss2 Gene Summary [Rat]
Enables acetate-CoA ligase activity. Involved in acetate biosynthetic process and propionate biosynthetic process. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acss2 |
| Official Name | acyl-CoA synthetase short-chain family member 2 [Source:RGD Symbol;Acc:1305489] |
| Ensembl ID | ENSRNOG00000018755 |
| Bio databases IDs | |
| Aliases | acyl-CoA synthetase short-chain family member 2 |
| Synonyms | 1110017C11Rik, ACAS, Acas1, ACAS2, ACECS, AceCS1, Acetyl-coa synthetase 1, amp forming, ACS, Acs1, ACSA, Acss2 (predicted), acyl-CoA synthetase short-chain family member 2, dJ1161H23.1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acss2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription co-activator
- acetate--CoA ligase
- Adenylate forming domain, Class I superfamily
- chromatin binding
- enzyme
- protein binding
- acetoacetyl-CoA synthase
- Acetyl-coenzyme A synthetase N-terminus
- benzoate-CoA ligase family
- AMP-binding enzyme
- acyl-CoA ligase (AMP-forming), exosortase A-associated
- acetate-CoA ligase
- propionate-CoA ligase
- acetate-CoA ligase (ADP-forming)
- AMP-binding enzyme C-terminal domain
- amino acid adenylation domain
Pathways
Biological processes and signaling networks where the Acss2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver neoplasia
- epithelial neoplasia
- neoplasia
- epithelial cancer
- cancer
- digestive system cancer
- abdominal cancer
- diabetic nephropathy
- depressive disorder
- hepatocellular carcinoma
role in cell
- expression in
- growth
- synthesis in
- quantity
- invasion by
- cellular infiltration by
- upregulation in
- acetylation in
- formation in
- thickening
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acss2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-term memory
- positive regulation of transcription, DNA-dependent
- acetyl-CoA biosynthetic process
- propionate biosynthetic process
- lipid biosynthetic process
- acetate biosynthetic process
- acetyl-CoA biosynthetic process from acetate
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrial matrix
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- AMP binding
- acetate-CoA ligase activity
- protein binding
- transcription coactivator activity
- propionate-CoA ligase activity
- chromatin binding