Padi2 Gene Summary [Rat]
Enables protein-arginine deiminase activity. Predicted to be involved in several processes, including estrogen receptor signaling pathway; substantia nigra development; and transcription initiation-coupled chromatin remodeling. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in euchromatin. Predicted to be active in cytoplasm and nucleus. Orthologous to human PADI2 (peptidyl arginine deiminase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Padi2 |
| Official Name | peptidyl arginine deiminase 2 [Source:RGD Symbol;Acc:3288] |
| Ensembl ID | ENSRNOG00000007574 |
| Bio databases IDs | |
| Aliases | peptidyl arginine deiminase 2 |
| Synonyms | KIAA0994, mKIAA0994, PAD2, PAD-H19, Pdi, PDI2, peptidyl arginine deiminase 2, peptidyl arginine deiminase, type II |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Padi2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-arginine deiminase
- Protein-arginine deiminase (PAD) N-terminal domain
- Cupredoxin superfamily
- Protein-arginine deiminase (PAD)
- protein homodimerization
- enzyme
- estrogen receptor binding
- Protein-arginine deiminase (PAD) middle domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- adenoma formation
- growth hormone prolactin producing pituitary adenoma
- head and neck neuroendocrine neoplasia
- renal cell cancer
- prolactinoma
- normal tension glaucoma
- renal cell carcinoma
- rheumatoid arthritis-associated interstitial lung disease
- congenital clavicular hypoplasia
role in cell
- expression in
- proliferation
- tumorigenicity
- osteogenic differentiation
- senescence
- gel contraction by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- azurophil granule lumen
- Extracellular Space
- cytosol
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Padi2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- positive regulation of gene expression, epigenetic
- negative regulation of chemokine-mediated signaling pathway
- intracellular estrogen receptor signaling pathway
- substantia nigra development
Cellular Component
Where in the cell the gene product is active
- nucleus
- euchromatin
- extracellular vesicular exosome
- cytoplasm
- cytosol
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein-arginine deiminase activity
- calcium ion binding
- estrogen receptor binding