Mkrn1 Gene Summary [Rat]
Predicted to enable chromatin binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mkrn1 |
| Official Name | makorin ring finger protein 1 [Source:RGD Symbol;Acc:1303251] |
| Ensembl ID | ENSRNOG00000009280 |
| Bio databases IDs | |
| Aliases | makorin ring finger protein 1 |
| Synonyms | makorin ring finger protein 1, makorin, ring finger protein, 1, RFP, RNF61 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mkrn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- E3 ubiquitin-protein ligase makorin, C-terminal
- zinc finger
- CCCH-type zinc finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- chromatin binding
- enzyme
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
- zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- backache
- organismal death
- colorectal cancer
regulated by
- LY-411,575
- ESX1
- cisplatin
- PTEN
- mibolerone
role in cell
- degradation in
- differentiation
- expression in
- cell viability
- migration
- cell death
- invasion by
- colony formation by
- replication in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- dendrite initial segments
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mkrn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding