Kcnh1 Gene Summary [Rat]
Enables several functions, including 14-3-3 protein binding activity; calmodulin binding activity; and delayed rectifier potassium channel activity. Involved in cellular response to calcium ion; potassium ion transmembrane transport; and startle response. Located in several cellular components, including axolemma; neuronal cell body; and nuclear inner membrane. Part of potassium channel complex. Is active in postsynaptic density membrane and presynaptic membrane. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human KCNH1 (potassium voltage-gated channel subfamily H member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Kcnh1 |
| Official Name | potassium voltage-gated channel subfamily H member 1 [Source:RGD Symbol;Acc:68398] |
| Ensembl ID | ENSRNOG00000003841 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel subfamily H member 1 |
| Synonyms | EAG, EAG1, hEAG, hEAG1, Hs.553187, K(V)10.1, Kv10.1, M-eag, mEAG1, potassium voltage-gated channel, subfamily H (eag-related), member 1, potassium voltage-gated channel subfamily H member 1, TMBTS, ZLS, ZLS1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- delayed rectifier potassium channel
- protein kinase binding
- Ion transport protein
- calmodulin binding
- PAS domain S-box
- PAS
- protein binding
- pore domain
- identical protein binding
- ion channel
- PAS fold
- Cyclic nucleotide-monophosphate binding domain
- phosphatidylinositol binding
- nucleotide-binding domain
- Cyclic nucleotide-binding domain
- binding protein
- PAS domain
- transmembrane domain
- ion channel binding
- C-terminal assembly domain
- assembly domain
- Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
- voltage-gated ion channel
- CAP_ED
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- neoplasia
- epithelial neoplasia
- cancer
- liver neoplasia
- Zimmermann-Laband syndrome type 1
- hereditary disorder
- KCNH1 associated disorder
- Temple-Baraitser syndrome
regulates
- K+
- ion
- cyclin D
- cdc2
- catecholamine
- KCNH1
- LY 97241
role in cell
- growth
- invasion by
- migration
- proliferation
- formation
- formation in
- length
- quantity
- cell cycle progression
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cell surface
- perinuclear region
- cellular membrane
- primary cilia
- presynaptic membrane
- synaptic membrane
- lateral plasma membrane
- endosomal membrane
- inner nuclear membrane
- axonal membrane
- transverse tubules
- perikaryon
- axons
- dendrites
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnh1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- regulation of membrane potential
- potassium ion transmembrane transport
- cellular response to calcium ion
- myoblast fusion
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- presynaptic membrane
- dendrite
- nuclear inner membrane
- intracellular membrane-bounded organelle
- voltage-gated potassium channel complex
- perikaryon
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- delayed rectifier potassium channel activity
- cyclic nucleotide binding