Fuca1 Gene Summary [Rat]
Enables carbohydrate binding activity and fucosidase activity. Predicted to be involved in fucose metabolic process and glycoside catabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in lysosome. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in fucosidosis. Orthologous to human FUCA1 (alpha-L-fucosidase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fuca1 |
| Official Name | alpha-L-fucosidase 1 [Source:RGD Symbol;Acc:2636] |
| Ensembl ID | ENSRNOG00000009325 |
| Bio databases IDs | |
| Aliases | alpha-L-fucosidase 1 |
| Synonyms | 0610006A03Rik, 9530055J05Rik, Afuc, alpha-L-fucosidase 1, FUCA, fucosidase, alpha-L- 1, tissue, fucosidase, α-L- 1, tissue, α-L-fucosidase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fuca1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha-L-fucosidase C-terminal domain
- Alpha amylase catalytic domain family
- enzyme
- fucosidase
- protein binding
- carbohydrate binding
- alpha-L-fucosidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fucosidosis
- hereditary disorder
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
- lung adenocarcinoma formation
- EGFR expression positive non-squamous non-small cell lung cancer
- amyotrophic lateral sclerosis
- diabetes mellitus
- stuttering
- astrocytosis
regulates
- cholesterol
- fucose
- enzyme
role in cell
- formation
- abnormal morphology
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- azurophil granule lumen
- Extracellular Space
- lysosome
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fuca1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoside catabolic process
- glycolipid catabolic process
- fucose metabolic process
- glycosaminoglycan catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- lysosomal lumen
- extracellular region
- azurophil granule lumen
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- alpha-L-fucosidase activity