Prkd3 Gene Summary [Rat]
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in ciliary basal body; nucleoplasm; and plasma membrane. Predicted to be active in cytosol. Orthologous to human PRKD3 (protein kinase D3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkd3 |
| Official Name | protein kinase D3 [Source:RGD Symbol;Acc:1310236] |
| Ensembl ID | ENSRNOG00000005289 |
| Bio databases IDs | |
| Aliases | protein kinase D3 |
| Synonyms | 4930557O20Rik, 5730497N19Rik, EPK2, nPKC-NU, PKC-NU, PKD3, PRKCN, protein kinase D3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prkd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- PH domain
- protein kinase C
- Pleckstrin homology-like domain
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Prkd3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Aldosterone Signaling in Epithelial Cells
- Androgen Signaling
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Axonal Guidance Signaling
- Breast Cancer Regulation by Stathmin1
- Calcium-induced T Lymphocyte Apoptosis
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- Cholecystokinin/Gastrin-mediated Signaling
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- CREB Signaling in Neurons
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endothelin-1 Signaling
- eNOS Signaling
- ErbB Signaling
- ErbB4 Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- prostatic neoplasm
- prostatic neoplasia
- Alzheimer disease
- gastric adenocarcinoma
- gastric epithelial cancer
- eosinophilic esophagitis
- dementia
role in cell
- proliferation
- generation
- apoptosis
- activation in
- expression in
- differentiation
- signaling in
- phosphorylation in
- accumulation in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- basal bodies
- Golgi Apparatus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prkd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipase C-activating G-protein coupled receptor signaling pathway
- protein kinase C-activating G-protein coupled receptor signaling pathway
- protein phosphorylation
- intracellular signal transduction
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein serine/threonine kinase activity
- kinase activity
- protein kinase C activity