Vav2

Predicted to enable epidermal growth factor receptor binding activity; guanyl-nucleotide exchange factor activity; and phosphotyrosine residue binding activity. Predicted to be involved in several processes, including immune response-regulating cell surface receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and small GTPase-mediated signal transduction. Predicted to act upstream of or within lamellipodium assembly. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Orthologous to human VAV2 (vav guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vav2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Vav2 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Vav2 gene, providing context for its role in the cell.