Osgep Gene Summary [Rat]
Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 3. Orthologous to human OSGEP (O-sialoglycoprotein endopeptidase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Osgep |
| Official Name | O-sialoglycoprotein endopeptidase [Source:RGD Symbol;Acc:1308578] |
| Ensembl ID | ENSRNOG00000009333 |
| Bio databases IDs | |
| Aliases | O-sialoglycoprotein endopeptidase |
| Synonyms | 1500019L24Rik, GAMOS3, GCPL-1, KAE1, OSGEP1, O-sialoglycoprotein endopeptidase, PRSMG1, TCS3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Osgep often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- universal archaeal protein Kae1
- metallohydrolase, glycoprotease/Kae1 family
- tRNA threonylcarbamoyl adenosine modification protein TsaD
- protein binding
- Non-amino-acyl group acyltransferase
- O-sialoglycoprotein endopeptidase
- tRNA N6-adenosine threonylcarbamoyltransferase
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Osgep gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- EKC/KEOPS complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding