Spn Gene Summary [Rat]
Enables protein domain specific binding activity. Involved in several processes, including T cell receptor signaling pathway; monocyte activation; and thymocyte aggregation. Located in cell surface; cleavage furrow; and microvillus. Orthologous to human SPN (sialophorin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spn |
| Official Name | sialophorin [Source:RGD Symbol;Acc:3750] |
| Ensembl ID | ENSRNOG00000036711 |
| Bio databases IDs | |
| Aliases | sialophorin |
| Synonyms | A630014B01Rik, CD43, GALGP, GPL115, LEU-22, Leukosialin, LOC101929889, LSN, Lsn1, Ly-48, sialophorin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ERM binding domain
- Hsp70 protein binding
- cytoplasmic domain
- RXXsL motif
- ectodomain
- heat shock protein binding
- transmembrane domain
- intracellular domain
- protein domain specific binding
- protein binding
- cytosolic tail domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Spn gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- follicular B-cell or T-cell lymphoma
- neoplasia
- abdominal aortic aneurysm
- follicular B-cell lymphoma
- follicular non-Hodgkin disease
- splenic marginal zone B-cell lymphoma
- splenic cancer
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- colorectal cancer
role in cell
- proliferation
- phosphorylation in
- migration
- growth
- aggregation
- cell death
- differentiation
- adhesion
- binding
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
- uropod
- membrane rafts
- cleavage furrow
- microvilli
- plasma
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic signaling pathway
- chemotaxis
- immune response
- positive regulation of tumor necrosis factor production
- negative regulation of type IV hypersensitivity
- regulation of immune response
- T cell costimulation
- signal transduction
- negative regulation of cell adhesion
- establishment or maintenance of cell polarity
- cell surface receptor signaling pathway
- T-helper 1 cell lineage commitment
- positive regulation of T cell proliferation
- defense response to bacterium
- response to protozoan
- positive regulation of T cell migration
- cellular defense response
- regulation of T cell migration
- negative regulation of T cell proliferation
- positive regulation of protein phosphorylation
- T cell proliferation
- leukocyte tethering or rolling
- negative thymic T cell selection
- regulation of defense response to virus
Cellular Component
Where in the cell the gene product is active
- basement membrane
- extracellular space
- extracellular vesicular exosome
- uropod
- PML body
- microvillus
- membrane
- external side of plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- heat shock protein binding
- protein binding
- transmembrane signaling receptor activity
- Hsp70 protein binding