Dis3 Gene Summary [Rat]
Predicted to enable 3'-5'-RNA exonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in RNA metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Orthologous to human DIS3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dis3 |
| Official Name | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [Source:RGD Symbol;Acc:1304646] |
| Ensembl ID | ENSRNOG00000009125 |
| Bio databases IDs | |
| Aliases | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease |
| Synonyms | 2810028N01Rik, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease, dis3p, EXOSC11, KIAA1008, RGD1304646, RRP44 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dis3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cold shock domain
- Dis3-like cold-shock domain 2 (CSD2)
- Rrp44-like cold shock domain
- VacB and RNase II family 3'-5' exoribonucleases
- enzyme
- protein binding
- This domain is the catalytic domain of ribonuclease II
- 3'-5' exoribonuclease
- endonuclease
- ribonuclease R
- S1 domain
- PIN domain
- RNB domain
- guanyl-nucleotide exchange factor
- Large family of predicted nucleotide-binding domains
- PIN (PilT N terminus) domain: Superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- plasma cell myeloma
- COVID-19
- short telomere syndrome
- prostatic carcinoma
- prostate cancer
regulates
- GDP
role in cell
- cell viability
- olaparib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dis3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear mRNA surveillance of mRNA 3'-end processing
- CUT catabolic process
- rRNA catabolic process
- RNA processing
- rRNA processing
- RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasmic exosome (RNase complex)
- nuclear exosome (RNase complex)
- nucleus
- membrane
- cytosol
- nucleolus
- exosome (RNase complex)
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 3'-5'-exoribonuclease activity
- RNA binding
- protein binding
- endonuclease activity
- guanyl-nucleotide exchange factor activity