Itpr3 Gene Summary [Rat]
Enables several functions, including alcohol binding activity; identical protein binding activity; and inositol 1,4,5-trisphosphate-gated calcium channel activity. Involved in G protein-coupled receptor signaling pathway; cellular response to cAMP; and positive regulation of cytosolic calcium ion concentration. Located in several cellular components, including apical plasma membrane; brush border; and nuclear outer membrane. Is active in endoplasmic reticulum membrane and presynapse. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease and type 1 diabetes mellitus. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itpr3 |
| Official Name | inositol 1,4,5-trisphosphate receptor, type 3 [Source:RGD Symbol;Acc:2934] |
| Ensembl ID | ENSRNOG00000052795 |
| Bio databases IDs | |
| Aliases | inositol 1,4,5-trisphosphate receptor, type 3 |
| Synonyms | CMT1J, inositol 1,4,5-triphosphate receptor 3, inositol 1,4,5-trisphosphate receptor type 3, inositol 1,4,5-trisphosphate receptor, type 3, IP3R, IP3R-3, IP3R3X, LOC105375023, tf |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itpr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- inositol 1,4,5-triphosphate-sensitive calcium-release channel
- calcium ion transporter
- Ion transport protein
- ATP binding
- calcium ion binding
- RIH domain
- MIR domain
- protein binding
- identical protein binding
- beta-trefoil_MIR
- ion channel
- calcium-release channel
- phosphatidylinositol binding
- conserved domain
- binding protein
- zinc ion binding
- RyR and IP3R Homology associated
- Inositol 1,4,5-trisphosphate/ryanodine receptor
- tail domain
Pathways
Biological processes and signaling networks where the Itpr3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Calcium Signaling
- CCR3 Signaling in Eosinophils
- Cellular Effects of Sildenafil (Viagra)
- Cholecystokinin/Gastrin-mediated Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- EGF Signaling
- eNOS Signaling
- Erythropoietin Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- GDNF Family Ligand-Receptor Interactions
- Glioblastoma Multiforme Signaling
- Gustation Pathway
- Netrin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Nitric Oxide Signaling in the Cardiovascular System
- nNOS Signaling in Skeletal Muscle Cells
- Renin-Angiotensin Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- eczema
- schizophrenia
- osteoarthritis
- obesity
- weight loss
- insulin-dependent diabetes mellitus
- organismal death
- metabolic syndrome X
- COVID-19
- cancer
role in cell
- activation in
- expression in
- proliferation
- phosphorylation in
- apoptosis
- cell death
- growth
- survival
- number
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- presynaptic regions
- cell surface
- apical compartment
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- apical membrane
- basolateral membrane
- mitochondria-associated membranes
- nucleoplasm
- nucleoli
- outer nuclear membrane
- nuclear envelope
- neurites
- secretory granules
- brush border
- perikaryon
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Itpr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion homeostasis
- sensory perception of taste
- sensory perception of umami taste
- G-protein coupled receptor signaling pathway
- sensory perception of sweet taste
- memory
- elevation of cytosolic calcium ion concentration
- protein homotetramerization
- response to calcium ion
- sensory perception of bitter taste
- long-term synaptic potentiation
- release of sequestered calcium ion into cytosol
- calcium-mediated signaling
Cellular Component
Where in the cell the gene product is active
- myelin sheath
- sarcoplasmic reticulum
- platelet dense tubular network membrane
- endoplasmic reticulum
- nuclear outer membrane
- receptor complex
- neuronal cell body
- nucleolus
- plasma membrane
- nucleoplasm
- endoplasmic reticulum membrane
- secretory granule membrane
- brush border
- apical part of cell
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- calcium-release channel activity
- protein binding
- calcium ion binding
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
- phosphatidylinositol binding
- inositol hexakisphosphate binding
- inositol 1,3,4,5 tetrakisphosphate binding
- inositol 1,4,5 trisphosphate binding