Rpl4 Gene Summary [Rat]
Enables 5S rRNA binding activity. Involved in brainstem development; cell differentiation; and positive regulation of axon extension. Located in A band. Part of cytosolic large ribosomal subunit. Is active in postsynaptic density. Orthologous to human RPL4 (ribosomal protein L4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl4 |
| Official Name | ribosomal protein L4 [Source:RGD Symbol;Acc:619824] |
| Ensembl ID | ENSRNOG00000009378 |
| Bio databases IDs | |
| Aliases | ribosomal protein L4 |
| Synonyms | 2010004J23RIK, L4, ribosomal protein L4, RL1, uL4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rpl4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- 5S rRNA binding
- enzyme
- protein binding
- Ribosomal protein L4/L1 family
- 60S ribosomal protein L4 C-terminal domain
- RNA binding
Pathways
Biological processes and signaling networks where the Rpl4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- myelodysplastic syndrome
- squamous-cell carcinoma
- squamous cell cancer
- cholangiocarcinoma
- cholangiocarcinoma cancer
regulates
- genomic DNA
- histone H3
- Ebna1
- TP53
role in cell
- activation in
- quantity
- formation
- extension
- binding in
- formation in
- outgrowth
- outgrowth in
- ubiquitination in
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- ribosome
- Nucleus
- Endoplasmic Reticulum
- sarcomere
- cytosol
- granular components
- nucleoli
- nuclear bodies
- rough endoplasmatic reticulum
- membrane processes
- perikaryon
- postsynaptic density
- sensory axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rpl4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- focal adhesion
- cytosolic ribosome
- cytoplasm
- membrane
- cytosol
- rough endoplasmic reticulum
- cytosolic large ribosomal subunit
- nucleolus
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- structural constituent of ribosome