Hmgcl Gene Summary [Rat]
Enables carboxylic acid binding activity; fatty-acyl-CoA binding activity; and hydroxymethylglutaryl-CoA lyase activity. Involved in several processes, including ketone body biosynthetic process; liver development; and response to fatty acid. Predicted to be located in peroxisome. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency and amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmgcl |
| Official Name | 3-hydroxy-3-methylglutaryl-CoA lyase [Source:RGD Symbol;Acc:620554] |
| Ensembl ID | ENSRNOG00000009422 |
| Bio databases IDs | |
| Aliases | 3-hydroxy-3-methylglutaryl-CoA lyase |
| Synonyms | 3-hydroxy-3-methylglutaryl-CoA lyase, 3-hydroxy-3-methylglutaryl-Coenzyme A lyase, HL, HMGCL1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hmgcl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- TIM-like beta/alpha barrel domains
- HMGL-like
- acyl-CoA binding
- metal ion binding
- enzyme
- hydroxymethylglutaryl-CoA lyase
- manganese ion binding
- structural molecule
- magnesium ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- HMG-CoA lyase deficiency
- deficiency of long-chain 3-hydroxyacyl-coenzyme A dehydrogenase
- hereditary disorder
- hypoglycemia
- metastasis
- Alzheimer disease
- hepatocellular carcinoma
- experimentally-induced diabetes
regulates
- lipid
- ketone body
- leucine
- acyl-coenzyme A
role in cell
- migration
- abnormal morphology
- invasion by
- organization
- ketogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- peroxisomal matrix
- Mitochondria
- cytosol
- mitochondrial matrix
- peroxisomes
- plasma
- peroxisomal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hmgcl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid metabolic process
- leucine catabolic process
- ketone body biosynthetic process
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- peroxisome
- mitochondrial matrix
- mitochondrion
- cytosol
- macromolecular complex
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- metal ion binding
- hydroxymethylglutaryl-CoA lyase activity
- structural molecule activity
- manganese ion binding